L-HOMOSERINE LACTONE HYDROBROMIDE
(S)-(-)-Alpha-Amino-Gamma-butyrolactone hydrobromide
CAS: 15295-77-9
Molecular Formula: C4H8BrNO2
L-HOMOSERINE LACTONE HYDROBROMIDE - Names and Identifiers
L-HOMOSERINE LACTONE HYDROBROMIDE - Physico-chemical Properties
| Molecular Formula | C4H8BrNO2 |
| Molar Mass | 182.02 |
| Melting Point | 225°C (dec.)(lit.) |
| Boling Point | 281.4°C at 760 mmHg |
| Flash Point | 124°C |
| Solubility | Methanol (Slightly), Water (Slightly) |
| Vapor Presure | 0.00233mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear yellow to brownish, may darken on storage |
| BRN | 3912375 |
| Storage Condition | 2-8°C |
| Sensitive | Hygroscopic |
| Physical and Chemical Properties | Sensitivity: hydrogen WGK Germany:3 |
L-HOMOSERINE LACTONE HYDROBROMIDE - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3-10 |
| HS Code | 29420000 |
L-HOMOSERINE LACTONE HYDROBROMIDE - Introduction
L-(-)-α-amino-γ-butyrolactone hydrobromide is an organic compound with the chemical formula C10H18BrNO2. The following is an introduction to some of its properties, uses, methods and safety information:
Nature:
-Appearance: Usually colorless crystalline solid or white crystalline powder.
-Melting point: about 132-135°C.
-Solubility: Slightly soluble in water, soluble in ethanol, ethers and chloroform and other organic solvents.
-Optical properties: It is an optically active compound with negative optical rotation.
Use:
-Pharmaceutical field: L-(-)-α-amino-γ-butyrolactone hydrobromide is a pharmaceutical intermediate that can be used to synthesize some drugs. For example, it is used as a precursor for the synthesis of some sedative, anxiolytic and antidepressant drugs.
Method:
The preparation of L-(-)-α-amino-γ-butyrolactone hydrobromide can be carried out by the following steps:
1. First, the butanone is reacted with an electrophilic nitrogen atom reagent (such as isocyanate or sulfoxide, etc.) under alkaline conditions to generate the corresponding cyclic ketimine compound.
2. Then, the obtained cyclic ketimine is reacted with hydrobromic acid under alkaline conditions to cleave its ring and form the final target product L-(-)-Α-amino-γ-butyrolactone hydrobromide.
Safety Information:
The safety data of L-(-)-α-amino-γ-butyrolactone hydrobromide is limited, but as an organic compound, it may have certain toxicity to the human body. Use in accordance with appropriate safety practices, including wearing protective gloves and glasses, and avoiding inhalation, skin contact, or swallowing. If accidentally exposed to the compound, rinse immediately with plenty of water and seek medical help.
Nature:
-Appearance: Usually colorless crystalline solid or white crystalline powder.
-Melting point: about 132-135°C.
-Solubility: Slightly soluble in water, soluble in ethanol, ethers and chloroform and other organic solvents.
-Optical properties: It is an optically active compound with negative optical rotation.
Use:
-Pharmaceutical field: L-(-)-α-amino-γ-butyrolactone hydrobromide is a pharmaceutical intermediate that can be used to synthesize some drugs. For example, it is used as a precursor for the synthesis of some sedative, anxiolytic and antidepressant drugs.
Method:
The preparation of L-(-)-α-amino-γ-butyrolactone hydrobromide can be carried out by the following steps:
1. First, the butanone is reacted with an electrophilic nitrogen atom reagent (such as isocyanate or sulfoxide, etc.) under alkaline conditions to generate the corresponding cyclic ketimine compound.
2. Then, the obtained cyclic ketimine is reacted with hydrobromic acid under alkaline conditions to cleave its ring and form the final target product L-(-)-Α-amino-γ-butyrolactone hydrobromide.
Safety Information:
The safety data of L-(-)-α-amino-γ-butyrolactone hydrobromide is limited, but as an organic compound, it may have certain toxicity to the human body. Use in accordance with appropriate safety practices, including wearing protective gloves and glasses, and avoiding inhalation, skin contact, or swallowing. If accidentally exposed to the compound, rinse immediately with plenty of water and seek medical help.
Last Update：2024-04-09 21:01:54
